Pain & Inflammation Relief with Piperine


Pain & Inflammation Relief with Piperine

Piperine is the major alkaloid constituent present in P. nigrum (black pepper) and P. logum (long pepper). Piperine has been scientifically validated as a bioavailability enhancer. There are a few possible mechanisms by which piperine acts as bio-enhancers:

Promoting rapid absorption of nutrients/ medicines
Increasing blood supply to the GI tract
Increasing emulsifying content of the gut

Curcumin + Piperine = Bioavailability Increased by 2000%
In a human clinical trial evaluating the bioavailability of curcumin (2g) with the addition of piperine (20mg) administered orally, the serum samples showed that curcumin with piperine had 2000% better bioavailability than curcumin taken alone (P<0.001).[1]

In addition, piperine has been shown to enhance curcumin’s neuro-protective effect against anti-psychotic medications (ie. haloperidol).[2]

Piperine also increases the absorption and bioavailability of various other nutrients.

In a double-blind clinical study, beta-carotene plus piperine was shown to yield 160% greater area under the curve (AUC) of serum beta-carotene than beta-carotene plus placebo over a course of 14 days.[3]

In other clinical studies, piperine was shown to enhance the bioavailability of coenzyme Q10 (ubiquinone) by 130% over 21 days of supplementation,[4] as well as selenium (145%), vitamin B6 (216%), and resveratrol (229%).[5]

Piperine – A Supreme Anti-Inflammatory Agent
Piperine has been demonstrated to possess anti-inflammatory and immune-modulatory actions by inhibiting the maturation, migration, and T-cell stimulatory capacity of dendritic cells (DC) in vivo and in vitro, as well as affecting T cell cytokine secretion.[6] These findings suggest that piperine can be an excellent adjunct ingredient for various autoimmune and inflammatory disorders (eg. SLE, RA, IBD).

Is piperine contraindicated in arthritic patients with a nightshade (Solanacea) allergy?
Some practitioners are concerned about giving piperine-containing supplements to arthritic patients with a nightshade allergy under the consensus that nightshade family (Solanaceae) includes potatoes (Solanum tuberosum), tomatoes (Lycopersicon esculentum), eggplants (Solanum melongena), tobaccos (Nicotinana tabacum), and all types of peppers (Capsicum sp.) – EXCEPT black pepper.

Most people are not aware of the fact that black pepper (Piper sp.) belongs to the Piperaceae family, NOT the nightshade.[7] Piperine can actually be an excellent medicine working synergistically with other anti-inflammatory medicines eg. curcumin, boswellia to treat arthritis patients, and should not pose any problem with nightshade allergic individuals.

Clinical Applications (along with Boswellia and Curcumin):
Reduce inflammation and pain of joints caused by autoimmune conditions (eg. RA, Psoriasis, SLE)
Relieve inflammation and pain from OA, tendonitis and fibromalgia.
Noticeably reduce the hsCRP levels.

Shoba G, Joy D, Joseph T, Majeed M, Rajendra R, Srinvas PSSR. Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Medica (1998). Vol 64: 353-356.
Bishnoi M, Chopra K, Lu RZ, Kulkarni SK. Protective effect of curcumin and its combination with piperine (bioavailability enhancer) against haloperidol-associated neurotoxicity: cellular and neurochemical evidence. Neurotox Res (2011). Vol20:215-225.
Badmaev V, Majeed M, Norkus EP. Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. Nutrition Research (1999). Vol19(3):381-388.
Badmaev V, Majeed M, Prakash L. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr. Biochem. (2000). Vol11:109-113.
Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H, Ahmad N. Enhancing the bioavailability of resveratrol by combining it with piperine. Mol. Nutr. Food Res. (2011). Vol55:1169-1176.
Rogers GA. Immunomodulatory effects of piperine on dendritic cell function. Immunol. (2011). Vol30(4):1233-1242.
Childers NF, Margoles MS. An Apparent Relation of Nightshades (Solanaceae) to Arthritis. J Neuro Ortho Med Surgery (1993). Vol12:227-231.