Melatonin For Migraine Sufferers


Melatonin For Migraine Sufferers

Melatonin benefits go beyond improving sleep; the hormone may decrease migraine frequency and intensity, too.

The crushing pain, nausea, and light sensitivity of a migraine headache can wreak havoc on the lives of migraine sufferers. New research is pointing to surprising melatonin benefits that may offer new hope to migraineurs.

Melatonin, most commonly known as the sleep hormone, helps to control our circadian rhythm, the 24-hour cycle that tells our bodies when it is time to sleep. Although it’s primary function is biological timekeeping, researchers have found that it can also modulate and decrease pain, possibly playing an important a role in migraine prevention.

Melatonin benefits for pain

Produced by the pineal gland, melatonin is at its lowest level during the light of day and steadily increases to a maximum level late at night. Researchers noted that many people have less pain at night—just when melatonin is peaking. They looked deeper and learned that melatonin acts on the receptors for many pain-relieving molecules in the brain (eg, opioid receptors), leading to a decrease in pain sensations when melatonin levels are high. Melatonin supplements have been shown to lower pain intensity in conditions such as fibromyalgia, irritable bowel syndrome, and migraine headaches.

Decreased melatonin levels in migraine patients

Strengthening the link between melatonin and migraine, multiple studies have found that patients with migraine have significantly lower melatonin levels at night than healthy controls. Perhaps even more interesting is that melatonin levels in migraine patients do not increase during the menstrual cycle the way that they normally do, implicating melatonin as a factor in menstrual migraine, a very common occurrence for women.

Melatonin may prevent and treat migraine

Based on these findings, melatonin is being pursued as a possible therapeutic tool to prevent migraines. A clinical trial found that 3 mg of melatonin 30 minutes before bedtime helped to reduce the overall frequency, intensity, and duration of headaches for the subjects in the study. 25 out of the 32 participants saw a decrease in headache frequency of 50%, and 8 participants saw a complete remission of headaches. This study also found menstrual migraines to be improved as well for the female subjects.

Try melatonin for yourself

To try using melatonin as a preventative migraine treatment at home, take it 30 to 60 minutes before sleep on a daily basis. The most promising studies show a dosage of 3 mg to be effective in reduce migraine symptoms. Along with helping you to fall and stay asleep, a melatonin supplement might just help relieve some of your pain and let you live more migraine-free days, but remember there are multiple causes for migraines, and the best treatment is a whole-person approach that address the underlying cause. To your health!


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