Dr. Calabrese And Hormesis

In last week’s issue of Critical Review of Toxicology, Edward Calabrese, Ph.D., lays out his understanding of the mechanisms at play in hormesis.* Hormesis is a dose-response phenomenon characterized by low-dose stimulation and high-dose inhibition. Historically, dose-responses have been thought to occur in a linear fashion from low-dose to high. A non-linear response, such as the hormetic response, has potential application in most every scientific field. This paper offers the first wide-reaching documentation of mechanisms of hormetic dose/concentration responses. For the past 20 years, Calabrese has been at the center of much of the research on hormesis. He writes in the abstract:

Regardless of the model (i.e. in vitro or in vivo), inducing agent, endpoint, or receptor/cell signaling pathway mediated mechanism, the quantitative features of the hormetic dose/concentration responses are similar, suggesting that the magnitude of the response is a measure of biological plasticity, within a broad range of biological contexts. These findings represent an important advance in the understanding of the hormetic dose/concentration response, its generalizability and potential biomedical applications, including drug discovery/efficacy assessment and the risk assessment process.

I had the opportunity to hear Dr. Ed Calabrese’s keynote lecture on hormesis at the 28th annual American Association of Naturopathic Physicians annual convention in Keystone, Colo. earlier this month. I sat alongside hundreds of naturopathic physicians from all over America, leaning in, to better grasp the meaning of his research and possible relevance to an extensive list of fields including biology, toxicology, the environment, pharmacology and medicine. His talk was riveting, funny and had broad sweeping implications and applications.

Toxicology Rock Star: The Inspiring Story of Dr. Edward Calabrese, Hormesis and the Dose Response – By  Amy Rothenberg, ND

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